| 3. Kolo | ||||||||
|---|---|---|---|---|---|---|---|---|
| 03/11/2021 | 03:00 | CF Monterrey | CF Monterrey | - | Club Leon | Club Leon | -: - | |
| 9. Kolo | ||||||||
| 03/02/2021 | 23:00 | Atlas Guadalajara | Atlas Guadalajara | - | Athletic San Luis | Athletic San Luis | 3: 1 (1: 1) | |
| 03/03/2021 | 01:00 | UANL Tigres | UANL Tigres | - | Deportivo Toluca | Deportivo Toluca | 0: 1 (0: 0) | |
| 03/03/2021 | 03:00 | Club Leon | Club Leon | - | Puebla FC | Puebla FC | 1: 2 (1: 0) | |
| 03/04/2021 | 01:00 | FC Juárez | FC Juárez | - | CF Monterrey | CF Monterrey | 1: 6 (1: 2) | |
| 03/04/2021 | 01:00 | Bílé kohouti | Bílé kohouti | - | Deportivo Guadalajara | Deportivo Guadalajara | 2: 2 (1: 1) | |
| 03/04/2021 | 03:00 | Modrý kříž | Modrý kříž | - | Mazatlan FC | Mazatlan FC | 1: 0 (0: 0) | |
| 03/04/2021 | 03:06 | Club Tijuana | Club Tijuana | - | CF America | CF America | 0: 2 (0: 0) | |
| 03/05/2021 | 01:00 | Club Necaxa | Club Necaxa | - | CF Pachuca | CF Pachuca | 2: 2 (1: 1) | |
| 03/05/2021 | 03:00 | Pumas UNAM | Pumas UNAM | - | Santos Laguna | Santos Laguna | 1: 0 (0: 0) | |
| 10. Kolo | ||||||||
| 03/06/2021 | 01:30 | Athletic San Luis | Athletic San Luis | - | Deportivo Toluca | Deportivo Toluca | -: - | |
| 03/06/2021 | 03:30 | Puebla FC | Puebla FC | - | UANL Tigres | UANL Tigres | -: - | |
| 03/06/2021 | 23:00 | Atlas Guadalajara | Atlas Guadalajara | - | FC Juárez | FC Juárez | -: - | |
| 03/07/2021 | 01:00 | CF America | CF America | - | Club Leon | Club Leon | -: - | |
| 03/07/2021 | 01:06 | CF Monterrey | CF Monterrey | - | Bílé kohouti | Bílé kohouti | -: - | |
| 03/07/2021 | 03:00 | Mazatlan FC | Mazatlan FC | - | Deportivo Guadalajara | Deportivo Guadalajara | -: - | |
| 03/08/2021 | 01:06 | Santos Laguna | Santos Laguna | - | Club Necaxa | Club Necaxa | -: - | |
| 03/08/2021 | 03:00 | Pumas UNAM | Pumas UNAM | - | Modrý kříž | Modrý kříž | -: - | |
| 03/09/2021 | 03:00 | CF Pachuca | CF Pachuca | - | Club Tijuana | Club Tijuana | -: - | |
| 11. Kolo | ||||||||
| 13.03.2021 | 01:30 | Puebla FC | Puebla FC | - | Atlas Guadalajara | Atlas Guadalajara | -: - | |
| 13.03.2021 | 02:30 | FC Juárez | FC Juárez | - | Pumas UNAM | Pumas UNAM | -: - | |
| 03/14/2021 | 01:00 | Club Tijuana | Club Tijuana | - | Santos Laguna | Santos Laguna | -: - | |
| 03/14/2021 | 01:00 | UANL Tigres | UANL Tigres | - | Mazatlan FC | Mazatlan FC | -: - | |
| 03/14/2021 | 03:00 | Modrý kříž | Modrý kříž | - | CF Monterrey | CF Monterrey | -: - | |
| 03/14/2021 | 18:00 | Deportivo Toluca | Deportivo Toluca | - | CF Pachuca | CF Pachuca | -: - | |
| 15.03.2021 | 01:00 | Bílé kohouti | Bílé kohouti | - | Athletic San Luis | Athletic San Luis | -: - | |
| 15.03.2021 | 03:00 | Deportivo Guadalajara | Deportivo Guadalajara | - | CF America | CF America | -: - | |
| 16. 3. 21 | 03:00 | Club Leon | Club Leon | - | Club Necaxa | Club Necaxa | -: - |
| | | |
